![]() ![]() Many studies showed its large impact on the work of breathing during assisted ventilation and on alveolar ventilation during controlled ventilation. Often, the instrumental dead space is overlooked during mechanical ventilation. What is the dead space during invasive mechanical ventilation? ![]() Consequently with low tidal volumes and high respiratory rates the weight of the dead space (also referred to as VD/VT) is automatically increased. The alveolar ventilation is defined as the respiratory rate times (tidal volume – dead space volume). 45: 227–243.Based on the recently published paper “Impact of Respiratory Rate and Dead Space in the Current Era of Lung Protective Mechanical Ventilation”, we will discuss here briefly the different part of the dead space and how it can be reduced, as well as the relations with respiratory rate, tidal volume and alveolar ventilation (part 2). The physiologic basis of pulmonary gas exchange: implications for clinical interpretation of arterial blood gases. Philadelphia: Lippincott Williams & Wilkins. In: Lippincott's Pathophysiology Series: Pulmonary Pathophysiology. “Gas transport to and from peripheral tissues”. In: Fishman's Pulmonary Diseases and Disorders, edited by MA, Grippi (editor-in-chief), JA, Elias, JA, Fishman, RM, Kotloff, AI, Pack, RM, Senior (editors). “Clinical presentations: gas exchange and transport”. ![]()
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